Fas Ligand (Fas-L)
Gene Expression
OVERVIEW EXPLANATION
FAS-Ligand is a protein molecule that activates the apoptotic process, through its interaction with the FAS receptor, to destroy transformed or cancerous cells. Simultaneously FAS-Ligand sometimes triggers the destruction of the Immune System cells that also assist in the destructive process and some cancerous cells are able to survive. If FAS-Ligand is present in high quantities it is an indication that immuno-logical cells are being destroyed. When only low quantities are present it shows that the immunological cells are not under total control and are accumulating which could lead to the development of other pathological conditions.
DETAILED EXPLANATION
FAS-Ligand is a special protein molecule that is able to trigger Apoptosis (programmed cell death) in the FAS sensitive cells. The Immune System T cells, B cells and Natural Killer (NK) cells are FAS sensitive cells. On their surface there is a special receptor molecule called FAS or CD-95. When FAS Ligand interacts with the FAS receptor, the destructive mechanism of the Immune System cells is triggered. Activated T cells, B cells and NK cells have an increased number of FAS receptors, which make them more FAS sensitive. There is evidence that the Cancer Cells produce significant amounts of FAS-Ligand. This FAS L is able to trigger destruction of the cells of the Immune System, which would normally attack Cancer Cells. This means that the Cancer Cells avoid destruction whilst some of the cells of the Immune System can be destroyed. This phenomenon is known as the ‘immune escape’ of Cancer Cells.
This assay is designed to provide information related to the destruction of the immunological cells which could be induced by the transformed / Cancer Cells or the immunological self cells.
High quantities of FAS-Ligand are associated with the active destruction of major types pf the immunological cells. Low quantities show that there is a risk of the uncontrolled accumulation of some immunological cells which can result in various pathological conditions developing.
APPLICATION
This assay will provide extremely valuable and accurate information relating to all forms of cancer.
FAS-Ligand is a protein molecule that activates the apoptotic process, through its interaction with the FAS receptor, to destroy transformed or cancerous cells. Simultaneously FAS-Ligand sometimes triggers the destruction of the Immune System cells that also assist in the destructive process and some cancerous cells are able to survive. If FAS-Ligand is present in high quantities it is an indication that immuno-logical cells are being destroyed. When only low quantities are present it shows that the immunological cells are not under total control and are accumulating which could lead to the development of other pathological conditions.
DETAILED EXPLANATION
FAS-Ligand is a special protein molecule that is able to trigger Apoptosis (programmed cell death) in the FAS sensitive cells. The Immune System T cells, B cells and Natural Killer (NK) cells are FAS sensitive cells. On their surface there is a special receptor molecule called FAS or CD-95. When FAS Ligand interacts with the FAS receptor, the destructive mechanism of the Immune System cells is triggered. Activated T cells, B cells and NK cells have an increased number of FAS receptors, which make them more FAS sensitive. There is evidence that the Cancer Cells produce significant amounts of FAS-Ligand. This FAS L is able to trigger destruction of the cells of the Immune System, which would normally attack Cancer Cells. This means that the Cancer Cells avoid destruction whilst some of the cells of the Immune System can be destroyed. This phenomenon is known as the ‘immune escape’ of Cancer Cells.
This assay is designed to provide information related to the destruction of the immunological cells which could be induced by the transformed / Cancer Cells or the immunological self cells.
High quantities of FAS-Ligand are associated with the active destruction of major types pf the immunological cells. Low quantities show that there is a risk of the uncontrolled accumulation of some immunological cells which can result in various pathological conditions developing.
APPLICATION
This assay will provide extremely valuable and accurate information relating to all forms of cancer.
